S+SeqTrial Feature List
Improved Study Design
- Reduce costs and bring drugs to market sooner
with sequential studies
- Interactive interface makes it easy to explore
tradeoffs between designs
Comprehensive Design and Evaluation Tools
- Sequential designs in unified family of Kittelson
and Emerson, including all commonly used group
sequential designs
- Family of designs based on error spending function
of Lan and DeMets
- Comprehensive evaluation tools, including power,
conditional power, sample size distribution, inference
at the boundaries, and Bayesian analyses
Completely Extensible
- Powerful S language for extending functionality
to fit your needs; from small to large projects,
from simple to complex analyses
Flexible Monitoring Methods
- Implementation of stopping rules based on error
spending functions or constrained boundaries
Easily Analyze and Interpret Your Results
- Exact p-values
- Exact confidence intervals
- Bias adjusted estimates of treatment effect
Easy to Learn
- State-of-the art GUI (Graphical User Interface)
- Documentation designed for the clinical trialist
- Fully integrated with S-PLUS data analysis software
Advanced Visualization Tools
- Comprehensive set of specialized plots for designing
studies, including power curves, ASN (average
sample size) curves, and stopping probabilities
- Trellis graphics for powerful and effective
comparison of designs
Powerful Validation Techniques
- Results validated against standard designs in
the group sequential literature
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